Local gastric and serum amoxicillin concentrations after different oral application forms

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Local gastric and serum amoxicillin concentrations after different oral application forms.

The high recolonization rate after monotherapy of Helicobacter pylori-positive gastritis may be due to insufficient local drug concentrations. To investigate the role of local diffusion, we measured levels of amoxicillin, a drug with good in vitro activity against H. pylori, in the mucosa and serum. One gram of amoxicillin was given to healthy volunteers as a tablet (n = 6) or as water-dissolve...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 1993

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.37.7.1506